Efficient lipase-selective synthesis of dilauryl mannoses by simultaneous reaction–extraction system |
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Authors: | Wenbin Zhang Yinjiao Wang Khizar Hayat Xiaoming Zhang Abbas Shabbar Biao Feng Chengsheng Jia |
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Affiliation: | (1) State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, People’s Republic of China |
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Abstract: | An efficient method for enzymatic-selective synthesis of dilauryl mannoses was developed using lipase-catalyzed condensation of d-mannose and lauric acid in a simultaneous reaction–extraction system. The highest equilibrium conversion of diesters of 51% (1,6-diester: 14%; 3,6-diester: 18%; 4,6-diester: 19%) and the total conversion of mono and dilauryl mannoses of 76% were achieved at the n-hexane/acetonitrile ratio of 1:1, the molar ratio of lauric acid to mannose of 4:1, 60 g/l molecular sieves and 5 g/l lipase at 50°C for 72 h in 15 ml SRE system. The new system will be important for the synthesis of dilauryl mannoses. |
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Keywords: | Dilauryl mannose Lauric acid Lipase Mannose Selectivity Simultaneous reaction– extraction system |
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