Reproduction in mice: liver enlargement in mice during pregnancy and lactation |
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| Authors: | A Hollister P Okubara J G Watson S Chaykin |
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| Affiliation: | 1. Department of cardiology, Thorax Center, Erasmus MC, Rotterdam, The Netherlands;2. Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands;1. Department of Wildlife & Fisheries Sciences, Texas A&M University, 210 Nagle Hall, 2258 TAMU, College Station, TX 77843, USA;2. Department of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, 4474 TAMU, College Station, TX 77843, USA;3. East Foundation, 200 Concord Plaza Drive, Suite 410, San Antonio, TX 78216, USA;1. Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK;2. University of Veterinary Medicine in Vienna, Department of Integrative Biology and Evolution, Vienna, Austria;3. Nutrition Obesity Research Center, The University of Alabama at Birmingham, Birmingham, AL, USA;4. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China |
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| Abstract: | The mechanism of liver enlargement during pregnancy was investigated in the C57BL/6J strain of mice. The C57BL/6J female exhibited a two-fold increase in liver mass during pregnancy. After the completion of lactation the size of the liver was reduced. Liver growth was accomplished with no increase in hepatocyte number and without an increase in total liver DNA content. During the early stages of liver expansion in pregnant females, DNA synthesis could be turned on by partial hepatectomy. However, during the last few days of gestation DNA synthesis and liver growth in response to partial hepatectomy were inhibited. During lactation this inhibition of growth was maintained, but inhibition of DNA synthesis was partially lifted. DNA synthesis and liver growth in response to partial hepatectomy were normal after the termination of lactation. Because of the limited scope of this investigation the full implications of these findings are not yet certain. |
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