Serum Gc system in liver cirrhosis and hepatoma |
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Authors: | George Theodoropoulos Gerasimos Rigatos Andreas Babionitakis Athanasios Archimandritis Aristomenis Fertakis Kimon Melissinos |
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Affiliation: | (1) Department of Pathologic Physiology, Athens University Medical School, 609 Athens, Greece |
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Abstract: | Summary Serum Gc polymorphism was studied in 85 patients with liver cirrhosis, in 65 with cirrhosis plus hepatoma, and in 40 with hepatoma without cirrhosis. Six hundred unrelated healthy Greeks served as controls. The Gc 1-1 phenotype was found more frequently in patients who had cirrhosis with or without hepatoma but the incidence of the Gc1 gene was significantly higher in patients with cryptogenic-HBsAg negative cirrhosis. On the other hand, the Gc 2-2 phenotype was found about three times more frequently in patients who had hepatoma without cirrhosis, and the incidence of the Gc2 gene was significantly higher in the same group than in the controls. Consequently, it could be surmised that the Gc1 and the Gc2 genes predispose, under the influence of various factors, the development of cryptogenic cirrhosis and hepatoma without cirrhosis, respectively. |
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