Mapping of a Gene for Long QT Syndrome to Chromosome 4q25-27 |
| |
| Authors: | Jean-Jacques Schott Flavien Charpentier Sophie Peltier Patrick Foley Emmanuel Drouin Jean-Brieuc Bouhour Patricia Donnelly Gilles Vergnaud Lucien Bachner Jean-Paul Moisan Herv Le Marec and Olivier Pascal |
| |
| Institution: | Jean-Jacques Schott, Flavien Charpentier, Sophie Peltier, Patrick Foley, Emmanuel Drouin, Jean-Brieuc Bouhour, Patricia Donnelly, Gilles Vergnaud, Lucien Bachner, Jean-Paul Moisan, Hervé Le Marec, and Olivier Pascal |
| |
| Abstract: | Long QT syndrome (LQTS) is a heterogeneous inherited disorder causing syncope and sudden death from ventricular arrhythmias. A first locus for this disorder was mapped to chromosome 11p15.5. However, locus heterogeneity has been demonstrated in several families, and two other loci have recently been located on chromosomes 7q35-36 and 3p21-24. We used linkage analysis to map the locus in a 65-member family in which LQTS was associated with more marked sinus bradycardia than usual, leading to sinus node dysfunction. Linkage to chromosome 11p15.5, 7q35-36, or 3p21-24 was excluded. Positive linkage was obtained for markers located on chromosome 4q25-27. A maximal LOD score of 7.05 was found for marker D4S402. The identification of a fourth locus for LQTS confirms its genetic heterogeneity. Locus 4q25-27 is associated with a peculiar phenotype within the LQTS entity. |
| |
| Keywords: | |
|
|
