Rapid increase of mitochondrial uncoupling protein and its mRNA in stimulated brown adipose tissue. Use of a cDNA probe |
| |
| Authors: | D Ricquier G Mory F Bouillaud J Thibault J Weissenbach |
| |
| Affiliation: | Department of Medical Chemistry, University of Helsinki, Siltavuorenpenger 10 A, SF-00170 Helsinki 17, Finland |
| |
| Abstract: | The administration of thyroxine to neonatal rats stimulates RNA synthesis by neuronal nuclei isolated from the developing rat brain cortex. Glial nuclei are relatively resistant to thyroxine treatment. The activity of neuronal RNA polymerase II is particularly stimulated by the hormone. Thyroxine also affects neuronal chromatin structure as shown by changes in the relative proportion of different subnuclear fractions obtained by gentle micrococcal nuclease digestion of nuclei from hormone-treated rats. |
| |
| Keywords: | Thyroid hormone Development Rat brain cortex Brain cell nucleus RNA polymerase Micrococcal nuclease |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
