| 流行性出血热（EHF）地鼠肾细胞（GHKC）灭活疫苗的初步人体观察 |
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| 引用本文： | 宋干 黄永成. 流行性出血热（EHF）地鼠肾细胞（GHKC）灭活疫苗的初步人体观察[J]. 病毒学报, 1991, 7(2): 102-106 |
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| 作者姓名： | 宋干 黄永成 |
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| 作者单位： | 中国预防医学科学院病毒学研究所(宋干，杭长寿，李德新，刘为民，梁米芳，霍子威，张全福)，卫生部长春生物制品研究所(黄永成，郝富勇，郑晓丽，惠连，回良杰，李淑兰，王晓宏，傅增武)，卫生部长春生物制品研究所(王伟) |
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| 摘 要： |
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| 关 键 词： | 流行性出血热 地鼠肾细胞 灭活疫苗 |
A PRELIMINARY HUMAN TRIAL OF INACTIVATED GOLDEN HAMSTER KIDNEY CELL VACCINE AGAINST EPIDEMIC HEMORRHAGIC FEVER |
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| Song Gan Huang Yongcheng Hang Changshou Hao Fuyong Li Dexin Zheng Xiaoli Liu Weimin Hui Lian Liang Mifang Hui Liangjie Huo Ziwei Li Shulan Zhang Quanfu Wang Xiaohong Fu Zengwu Wang Wei. A PRELIMINARY HUMAN TRIAL OF INACTIVATED GOLDEN HAMSTER KIDNEY CELL VACCINE AGAINST EPIDEMIC HEMORRHAGIC FEVER[J]. Chinese journal of virology, 1991, 7(2): 102-106 |
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| Authors: | Song Gan Huang Yongcheng Hang Changshou Hao Fuyong Li Dexin Zheng Xiaoli Liu Weimin Hui Lian Liang Mifang Hui Liangjie Huo Ziwei Li Shulan Zhang Quanfu Wang Xiaohong Fu Zengwu Wang Wei |
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| Affiliation: | Song Gan Huang Yongcheng Hang Changshou Hao Fuyong Li Dexin Zheng Xiaoli Liu Weimin Hui Lian Liang Mifang Hui Liangjie Huo Ziwei Li Shulan Zhang Quanfu Wang Xiaohong Fu Zengwu Wang Wei |
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| Abstract: | The inactivated vaccine against epidemic hemorrhagic fever ( EHF ), Lot 88-17,was prepared with golden hamster kidney cell ( GHKC) culture, infected with the rat-type EHF virus, L99 strain, and inactivated with 0.025% formalin. 12 human volunteers were immunized with the vaccine, 10 of them on 0, 7, 28 days, and 2 on 0,7 days,and 0 , 28 days respec- tively, in order to assess the safety and ,the antibody responses of this vaccine. The results showed that, no obvious untoward reaction was observed. The vaccinees were followed up by successive bleedings after 28, 42, 180 and 360 days. The total possitive sero-conversion rates of IFA, ELISA antibodies were 100%, and that of neutralizing antibody ( EFRNT ) was also 100%, including sera of the two vaccinees received two doses of the vaccine. There were sera of 10 out of these 12 vaccinees, collected both on 180 days and 360 days later were still positive for neutralizing antibody. These data demonstrated that the vaccine was safe and could effectively induce specific antibody responses. |
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| Keywords: | Epidemic hemorrhagic fever Golden hamster kidneycell Inactivated vaccine Human trial |
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