Isolation of mutants with improved production of cAMP from Microbacterium sp. no. 205 (ATCC21376) |
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Authors: | Jiro Ishiyama |
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Institution: | (1) Research and Development Division, Kikkoman Corporation, 278 Noda-shi, Chiba-ken, Japan |
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Abstract: | Summary Mutants were isolated from Microbacterium sp. no. 205 (ATCC 21376) producing 13–30mm cyclic adenosine 3 ,5 -monophosphate (cAMP) by salvage biosynthesis, through sequential improvements of the bacterium for the purpose of improving cAMP production. The mutants produced 50–75 mm cAMP on 100 mm inosine 5 -monophosphate as a precursor. Mutants resistant to the inhibition of growth by cAMP at high concentrations were isolated; the resistance was one of four characteristics effective for improved production of cAMP. |
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