Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate |
| |
| Authors: | H S Sherratt S J Gatley T R DeGrado C K Ng J E Holden |
| |
| Affiliation: | Department of Pharmacological Sciences University of Newcastle upon Tyne Newcastle upon Tyne NE1 7RU, UK;Department of Medical Physics 1300 University Ave University of Wisconsin, Madison, WI 53706, USA |
| |
| Abstract: | Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold. |
| |
| Keywords: | POCA 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate IHDA |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
