Molecular characterization of HLA-A,B homologues in owl monkeys and other nonhuman primates |
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Authors: | Peter Parham Hidde L. Ploegh |
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Affiliation: | 1. The Biological Laboratories, Harvard University, 16 Divinity Avenue, 02138, Cambridge, Massachusetts
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Abstract: | Mouse anti-HLA-A, B monoclonal antibodies have been used to study the homologues of HLA-A, B antigens in other primate species. Immunoprecipitates of primate histocompatibility antigens from extracts of radioactively labeled lymphocytes were analyzed by SDS-polyacrylamide electrophoresis. Primate histocompatibility antigens appear to have similar molecular structure to human HLA antigens. Owl monkeys, which react polymorphically with some monomorphic anti-HLA antibodies, showed biochemical differences which correlated with the serological polymorphism. An antibody (W6/32) which only reacts with the HLA/β 2-microglobulin complex in humans and not with the free HLA heavy chain has the reverse specificity in some owl monkeys. |
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