Mutagenic effects of vinyl chloride on Drosophila melanogaster with and without pretreatment with sodium phenobarbiturate. |
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| Authors: | J Magnusson C Ramel |
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| Institution: | Environmental Toxicology Unit, Wallenberg Laboratory, University of Stockholm Sweden |
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| Abstract: | Treatment of Drosophila males with 1--20% vinyl chloride in air gave an increased frequency of complete and mosaic recessive lethals. Pretreatment with phenobarbiturate for 24 h caused an increase in the mutagenic effect of vinyl chloride. This indicates that the mixed-function oxygenase system can be induced in Drosophila in the same way as in mammals. |
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