蛋白激酶C同工酶分子结构及功能研究进展

蛋白激酶Ｃ（ＰＫＣ）是至少包括１１种亚型在内的丝／苏氨酸蛋白激酶家族,可分为传统型（ｃＰＫＣｓ）、新型（ｎＰＫＣｓ）、非典型（ａＰＫＣｓ）和ＰＫＣ－ｕ四大类。各ＰＫＣ亚型在ＡＴＰ结合位点、磷脂酰基转移位点、假性底物位点、佛波酯结合位点的氨基酸序列既高度保守又有变异。ＰＫＣ在机体内分布和作用十分广泛,本文主要介绍了ＰＫＣ在肿瘤形成、侵润和转移及肿瘤耐药性产生,调节造血干／祖细胞定向分化成熟,以及激素

Study on the molecular structure and function of protein kinase C isoenzyme

Protein kinase C (PKC) is a serine/threonine kinase family consisting at least 11 related isoenzymes, and it can be divided into four distinct classes, conventional PKC (cPKCs), novel or new PKC (nPKCs), atypical PKC (aPKCs), and PKC-u. All PKC members contain conserved and variant amino acid sequences in ATP binding sites, phosporyl transfer region, pseudosubstrate region, and phorbol ester binding sites. PKC isoenzymes exhibit distinct tissue distribution and play a critical role in cellular events. This review mainly summarized the PKC effects on tumorigenesis, tumor invasion and metastasis, tumor multidrug resistance, differentiation and development of hematopoietic progenitor cells, and hormonal production and secretion.