Influence of sarmesin on some dopamine-related types of behaviour |
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Authors: | Vasil Georgiev John M Matsoukas Daniela Georgieva Jana Tchekalarova and Ivan Todorov |
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Institution: | (1) Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;(2) Department of Chemistry, University of Patras, 26500 Patras, Greece |
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Abstract: | Summary The present study was undertaken to investigate the effects of sarmesin, an analogue of Sar1] angiotensin II (ANG II) where the tyrosine hydroxyl group in position 4 is methylated, on dopamine (DA)-related paradigms: locomotor and exploratory behaviour as well as apomorphine (3 mg/kg, ip)-induced stereotypy in rats. Sarmesin (0.5 and 1 g, icv) significantly decreased ambulation and rearing movements, and blocked the inhibitory effect of ANG II (0.1 g) on both types of activity. Sarmesin induced biphasic effects on apomorphine-induced stereotypy depending on the dose increase (0.5 and 5 g, icv) and decrease (10 g). Moreover, sarmesin (5 g) blocked the inhibitory effect of ANG II (2 g, icv) on apomorphine stereotypy. Taken together, these results suggest that sarmesin might interact with AT1 and AT2 receptor subtypes. The results further confirm the statement for ANG II-DA interaction in brain structures involved in these types of behaviour. |
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Keywords: | Sarmesin Angiotensin II Dopamine Ambulation Rearing Apomorphine stereotypy |
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