Synthesis of carbocyclic nucleosides bearing a cyclopropane ring. |
| |
| Authors: | Y Yamatoya M Ishikura N Katagiri |
| |
| Institution: | Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan. |
| |
| Abstract: | A carbocyclic cyclopropane fused nucleoside, 9-(c-4-hydroxymethylbicyclo3.1.0]hex-r-2-yl)-9H-adenine, has been efficiently synthesized from 2-azabicyclo-2.2.1]hex-5-en-3-one (ABH) in 6 steps, namely cyclopropanation, -reductive amide cleavage (RAC) reaction and adenine ring construction. |
| |
| Keywords: | |
|
|
