Affinity change of the adipocyte receptor fails to alter insulin-stimulated glucose transport |
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Authors: | Michael L. McCaleb and David B. Donner |
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Abstract: | Occupancy increased the affinity of the insulin receptor of the adipocyte. During the affinity change the half-maximal sensitivity of glucose transport to insulin stimulation was unaltered. Decreased maximum response of transport only occurred after the affinity change. There was not a simple relationship between receptor affinity and insulin stimulation of glucose transport in the adipocyte. |
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