6,7,4′-trihydroxyisoflavan: A potent and selective inhibitor of 5-lipoxygenase in human and porcine peripheral blood leukocytes |
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Authors: | P. Kuhl P. Shiloh H. Jha U. Murawski F. Zilliken |
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Affiliation: | Institut für Physiologische Chemie der Rheinischen Friedrich-Wilhelms-Universität zu Bonn, Nussallee 11, D-5300 Bonn, FRG |
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Abstract: | The effect of 6,74′-trihydroxyisoflavan on human platelet 12-lipoxygenase and human and porcine PMNL 5-lipoxygenase activities has been studied. 6,7,4′-Trihydroxyisoflavan was found to inhibit 5-lipoxygenase more strongly than 12-lipoxygenase; its concentration for 50% inhibition (IC50) was 1.6 μm for human and porcine 5-lipoxygenase adn 22 μM for human platelet 12-lipoxygenase. Inhibition of microsomal cyclooxygenase from ram seminal vesicles is exhibited at much higher concentrations of 6,7,4′-trihydroxyisoflavan (IC50 = 200 μM). |
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