|
|||||
|
|
Toxicity of 6-thioguanine and 8-azaguanine to non-dividing liver cell cultures |
|
| Authors: | Jules J. Berman Charles Tong Gary M. Williams |
| Affiliation: | (1) Department of Pathology, George Washington University Hospital, Washington, D.C., USA;(2) Naylor Dana Institute of Disease Prevention, American Health Foundation, Valhalla, New York, USA;(3) Naylor Dana Institute for Disease Prevention, American Health Foundation, Dana Road, 10595 Valhalla, New York, USA |
| Abstract: | 8-azaguanine and 6-thioguanine were both toxic to non-dividing liver cells in primary cultures. In addition, these agents were toxic to an established line of liver-derived epithelial cells brought to growth arrest by serum deprivation. These observations demonstrate that the toxicity of 8-azaguanine and 6-thioguanine can occur at least in part through mechanisms that do not involve effects on DNA synthesis or incorporation of the analogs into DNA.Abbreviations AG 8-azaguanine - ARL adult rat liver epithelial cell line - HGPRT hypoxanthine-guanine phosphoribosyl transferase - WME Williams Medium E |
| Keywords: | 8-azaguanine 6-thioguanine liver-derived epithelial cells serum deprivation |
| 本文献已被 SpringerLink 等数据库收录！ | |