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The four serotypes of dengue recognize the same putative receptors in Aedes aegypti midgut and Ae. albopictus cells |
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| Authors: | Ricardo F Mercado-Curiel Héctor Armando Esquinca-Avilés Rosalinda Tovar álvaro Díaz-Badillo Minerva Camacho-Nuez de Lourdes María Mu?oz |
| Affiliation: | (1) Department of Genetics and Molecular BiologyCentro de Investigacin y de Estudios Avanzados del Instituto Politcnico Nacional. Ave, Instituto Politcnico Nacional 2508 Col San Pedro Zacatenco, C.P, Mxico, D. F, 07360, Mxico;(2) Centro de Investigacin en Ciencia Aplicada y Tecnologa Avanzada del Instituto Politcnico Nacional, Postgrado en Tecnologa Avanzada, Legaria 694, Col. Irrigacin, Delg. Miguel Hidalgo C.P, Mxico, D. F, 11500, Mxico;(3) Genomic Sciences Program, Universidad Autnoma de la Ciudad de Mxico, Fray Servando Teresa de Mier, # 99, Col. Centro, CP, Mxico, D. F, 06080, Mxico;(4) Laboratory of Molecular Genetics, Universidad Autnoma de Chiapas, Chiapas, Mxico |
| Abstract: | BackgroundDengue viruses (DENV) attach to the host cell surface and subsequently enter the cell by receptor-mediated endocytosis. Several primary and low affinity co-receptors for this flavivirus have been identified. However, the presence of these binding molecules on the cell surface does not necessarily render the cell susceptible to infection. Determination of which of them serve as bona fide receptors for this virus in the vector may be relevant to treating DENV infection and in designing control strategies. |
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