An integrated approach to the prediction of domain-domain interactions |
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| Authors: | Hyunju Lee Minghua Deng Fengzhu Sun Ting Chen |
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| Affiliation: | (1) Department of Computer Science, University of Southern California, Los Angeles, CA 90089, USA;(2) School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing, 100871, P.R. China;(3) Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, 1050 Childs Way, Los Angeles, CA 90089-2910, USA |
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| Abstract: | Background The development of high-throughput technologies has produced several large scale protein interaction data sets for multiple species, and significant efforts have been made to analyze the data sets in order to understand protein activities. Considering that the basic units of protein interactions are domain interactions, it is crucial to understand protein interactions at the level of the domains. The availability of many diverse biological data sets provides an opportunity to discover the underlying domain interactions within protein interactions through an integration of these biological data sets. |
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