Analytical Method for the Fast Time-Domain Reconstruction of Fluorescent Inclusions In Vitro and In Vivo |
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Authors: | Sung-Ho Han |
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Institution: | Department of Radiology and Moores UCSD Cancer Center, University of California at San Diego, La Jolla, California |
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Abstract: | A novel time-domain optical method to reconstruct the relative concentration, lifetime, and depth of a fluorescent inclusion is described. We establish an analytical method for the estimations of these parameters for a localized fluorescent object directly from the simple evaluations of continuous wave intensity, exponential decay, and temporal position of the maximum of the fluorescence temporal point-spread function. Since the more complex full inversion process is not involved, this method permits a robust and fast processing in exploring the properties of a fluorescent inclusion. This method is confirmed by in vitro and in vivo experiments. |
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