Screening of melanin biosynthesis inhibitors from marine microalgae using Streptomyces bikiniensis bioassay |
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| Authors: | Yoji Wachi Koji Sode Kenichi Horikoshi Haruko Takeyama Tadashi Matsunaga |
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| Institution: | (1) Department of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, 184 Tokyo, Japan;(2) Safety and Analytical Research Center, Shiseido Research Center, Yokohama, 223 Kawasaki, Japan |
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| Abstract: | Summary Inhibitors of melanin biosynthesis from marine microalgae were screened against a melanin-producing microorganism, Streptomyces bikiniensis. From 28 marine microalgal strains, 5 were found showing inhibitory activity. Of these, the extracts (50 l, 2g total organic carbon/l) from two marine green algae showed strongly inhibited melanin biosynthesis, but showed less than 30 % inhibitory activity against mushroom tyrosinase. |
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