| 合成生物制造 |
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| 引用本文： | 李寅.合成生物制造[J].生物工程学报,2022,38(4):1267-1294. |
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| 作者姓名： | 李寅 |
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| 作者单位： | 中国科学院微生物研究所 中国科学院微生物生理与代谢工程重点实验室 微生物资源前期开发国家重点实验室, 北京 100101 |
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| 摘 要： | 本文对2021年《生物工程学报》在合成生物制造领域发表的综述和论文进行了评述.重点讨论了大肠杆菌、枯草芽孢杆菌、谷氨酸棒杆菌、酿酒酵母、丝状真菌以及非模式细菌、非传统酵母等主要底盘细胞的设计改造,氨基酸、有机酸、维生素、高级醇、天然化合物(萜类、黄酮类、生物碱类)、抗生素类、酶与生物催化产品、生物聚合物等产品的生物制造...
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| 关 键 词： | 合成生物学 生物制造 工程生物 初级代谢产物 次级代谢产物 细胞工厂 |
| 收稿时间： | 2022/4/11 0:00:00 |
Biomanufacturing driven by engineered microbes |
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| LI Yin.Biomanufacturing driven by engineered microbes[J].Chinese Journal of Biotechnology,2022,38(4):1267-1294. |
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| Authors: | LI Yin |
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| Institution: | CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | This article summarized the reviews and research articles published in Chinese Journal of Biotechnology in the field of biomanufacturing in 2021.The article covered major chassis cells such as Escherichia coli,Bacillus subtilis,Corynebacterium glutamicum,Saccharomyces cerevisiae,filamentous fungi,non-model bacteria and non-conventional yeasts.Moreover,this article summarized the advances in the production of amino acids,organic acids,vitamins,higher alcohols,natural compounds (terpenoids,flavonoids,alkaloids),antibiotics,enzymes and enzyme-catalyzed products,biopolymers,as well as the utilization of biomass and one-carbon materials.The key technologies used in the construction of cell factories,such as regulation,evolution,and high-throughput screening,were also included.This article may help the readers better understand the R & D trend in biomanufacturing driven by engineered microbes. |
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| Keywords: | synthetic biology biomanufacturing engineered microbes primary metabolites secondary metabolites cell factories |
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