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3-Lithioquinuclidin-2-ene: A novel intermediate for the synthesis of muscarinic agonists and antagonists |
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| Authors: | Gunnar Nordvall Staffan Sundquist Lisbeth Nilvebrant Uli Hacksell |
| Affiliation: | a Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Uppsala University, Box 574, S-751 23 Uppsala, Sweden. b Department of Pharmacology, Pharmacia AB, S-751 82 Uppsala, Sweden. |
| Abstract: | A method for the generation of 3-lithioquinuclidin-2-ene (3 as a nucleophilic intermediate for the synthesis of 3-substituted quinuclidin-2-enes is presented. |
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