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Effect of colony morphology variation of |
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| Authors: | Sarunporn Tandhavanant Aunchalee Thanwisai Direk Limmathurotsakul Sunee Korbsrisate Nicholas PJ Day Sharon J Peacock Narisara Chantratita |
| Affiliation: | 1.Department of Microbiology and Immunology, Faculty of Tropical Medicine,Mahidol University,Bangkok,Thailand;2.Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine,Mahidol University,Bangkok,Thailand;3.Department of Immunology, Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok,Thailand;4.Department of Tropical Hygiene, Faculty of Tropical Medicine,Mahidol University,Bangkok,Thailand;5.Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine,University of Oxford, Churchill Hospital,Oxford,UK;6.Department of Medicine,University of Cambridge, Addenbrooke's Hospital,Cambridge,UK |
| Abstract: | BackgroundPrimary diagnostic cultures from patients with melioidosis demonstrate variation in colony morphology of the causative organism, Burkholderia pseudomallei. Variable morphology is associated with changes in the expression of a range of putative virulence factors. This study investigated the effect of B. pseudomallei colony variation on survival in the human macrophage cell line U937 and under laboratory conditions simulating conditions within the macrophage milieu. Isogenic colony morphology types II and III were generated from 5 parental type I B. pseudomallei isolates using nutritional limitation. Survival of types II and III were compared with type I for all assays. |
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