Correlation between the Quantity of White Blood Cells and Their Volume Distribution Parameters in Humans

Using correlation and factor analyses, the following parameters were studied in males and females: correlations between the white blood cell (WBC) count; mean neutrophil, lymphocyte, and monocyte volume; volume variation; asymmetry coefficients; and volume distribution excess in populations of WBCs. A clear interrelationship between the quantity and the volume, i.e., the quality, was shown. The cosubordination relationship involves all studied classes of WBCs appearing as a parameter correlation within the distinct classes as well as between different classes. This phenomenon is strongly sex-specific. The relative quantity or cell volume is changed together with the concerted behavior of other WBC classes, i.e., content, volume, and distribution of the cells. It is suggested that such functional alterations are compensatory in nature and facilitate optimization of the capillary blood flow.