Somatostatin inhibits neutrophil elastase release in vitro |
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| Authors: | E O Adeyemi A P Savage S R Bloom H J Hodgson |
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| Affiliation: | Department of Medicine, Royla Postgraduate Medical School, Hammersmith Hospital, London. |
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| Abstract: | The influence of the long-acting somatostatin analogue, SMS 201-995, on FMLP-induced neutrophil elastase release in vitro has been investigated. Doses from 150 ng/ml upwards inhibited elastase release, with 100% inhibition by 2500 ng/ml. Inhibition was demonstrated both by an assay measuring elastase immunometrically and by an assay based on its enzyme activity. The demonstration that SMS 201-995 inhibits protease release from polymorphonuclear leukocytes may have implications for the long-term clinical use of this somatostatin analogue. |
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