Polymorphism at the apical membrane antigen 1 locus reflects the world population history of <Emphasis Type="Italic">Plasmodium vivax</Emphasis> |
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| Authors: | Priscila Grynberg Cor Jesus F Fontes Austin L Hughes Érika M Braga |
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| Institution: | 1.Departamento de Parasitologia,Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais,Belo Horizonte,Brazil;2.Departamento de Clínica Médica,Universidade Federal de Mato Grosso,Cuiabá,Brazil;3.Department of Biological Sciences,University of South Carolina,Columbia,USA |
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| Abstract: | Background In malaria parasites (genus Plasmodium), ama-1 is a highly polymorphic locus encoding the Apical Membrane Protein-1, and there is evidence that the polymorphism at this
locus is selectively maintained. We tested the hypothesis that polymorphism at the ama-1 locus reflects population history in Plasmodium vivax, which is believed to have originated in Southeast Asia and is widely geographically distributed. In particular, we tested
for a signature of the introduction of P. vivax into the New World at the time of the European conquest and African slave trade and subsequent population expansion. |
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