Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts |
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| Authors: | David Barrera Euclides Avila Guillermo Hernández Isabel Méndez Leticia González Ali Halhali Fernando Larrea Angélica Morales Lorenza Díaz |
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| Affiliation: | 1.Departamento de Biología de la Reproducción,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Tlalpan,México |
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| Abstract: | Background In pregnancy, maternal serum concentrations of calcitriol significantly rise as a result of increased renal and placental contribution in order to assure calcium supply for the developing fetus. Considering that placenta is a site for vitamin D activation, and the versatility and potency of calcitriol, it is feasible that this hormone participates in fetal/placental development and physiology. In the present work we studied calcitriol actions upon human chorionic gonadotropin (hCG) secretion and expression in cultured trophoblasts, as well as vitamin D receptor (VDR) and CYP27B1 immunolocalization in placental villi. |
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