Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis |
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Authors: | Shameek Biswas John D Storey Joshua M Akey |
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Affiliation: | (1) Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA;(2) Department of Biostatistics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA |
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Abstract: | Background The combination of gene expression profiling with linkage analysis has become a powerful paradigm for mapping gene expression quantitative trait loci (eQTL). To date, most studies have searched for eQTL by analyzing gene expression traits one at a time. As thousands of expression traits are typically analyzed, this can reduce power because of the need to correct for the number of hypothesis tests performed. In addition, gene expression traits exhibit a complex correlation structure, which is ignored when analyzing traits individually. |
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