Cilia and ciliopathies: From <Emphasis Type="Italic">Chlamydomonas</Emphasis> and beyond |
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Authors: | JunMin Pan |
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Institution: | 1.Department of Biological Sciences and Biotechnology,Tsinghua University,Beijing,China |
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Abstract: | The biological function of motile cilia/flagella has long been recognized. The non-motile primary cilium, once regarded as
a vestigial organelle, however, has been found recently to play unexpected roles in mammalian physiology and development.
Defects in cilia have profound impact on human health. Diseases related to cilia, collectively called ciliopathies include
male infertility, primary cilia dyskinesia, renal cyst formation, blindness, polydactyly, obesity, hypertension, and even
mental retardation. Our current understanding of cilia and ciliopathies has been fueled by basic research employing various
model organisms including Chlamydomonas, a unicellular green alga. This review article provides a general introduction to the cell biology of cilia and an overview
of various cilia-related diseases. |
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