Cell-Cell Interactions and Distal Outgrowth in Amphibian Limbs |
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Authors: | BRYANT, SUSAN V. HOLDER, NIGEL TANK, PATRICK W. |
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Affiliation: | Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, Irvine, California 92717 Department of Anatomy, King's College Strand, London WC2R 2LS, England Department of Anatomy, University of Arkansas for Medical Science 4301 W. Markham, Little Rock, Arkansas 72201 |
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Abstract: | SYNOPSIS. A current model concerning the process of limb regenerationin vertebrates is examined. According to this model (Bryantet al, 1981), new positional values in the proximal-distal limbaxis are laid down as a result of local interactions betweencells in the limb circumference. Cells with disparate circumferentialpositional values come together at the site of future outgrowthand intercalation between them generates more distal levelsof the pattern. The results of a number of experiments on surgicallycreated symmetrical limb stumps are discussed in relation tothis model. In addition, an extension of this model to accountfor digit formation is presented, and the implications of thisformulation for limb evolution are discussed. |
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