The dodo gene family encodes a novel protein involved in signal transduction and protein folding |
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Affiliation: | 1. Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan;2. Department of Integrative Medicine, Jinling Hospital, Nanjing, Jiangsu Province 210002, China;3. Division of Rheumatology, Department of Internal Medicine, Toho University, Tokyo 1538515, Japan |
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Abstract: | Recent studies in yeast, Drosophila and humans have revealed the existence of a highly conserved gene encoding a novel protein, Dodo, comprised of four modules: a WW domain, involved in protein–protein interactions, a peptidyl–prolyl cis–trans isomerase (PPIase) domain belonging to a recently described third family of PPIases involved in protein folding and unfolding, a nuclear localization motif and finally, a long, surface-exposed α-helix that is likely to be involved in binding to a cell cycle serine/threonine kinase. The genetic, molecular, biochemical and structural data are reviewed in the context of the potential biological properties of this new protein family. |
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