Isolation and characterization of a mammalian homolog of the Drosophila white gene |
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| Institution: | 1. Division of Pediatric Oncology, Dana-Farber Cancer Institute, Children''s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115 USA;2. Department of Pediatrics, Vanderbilt University School of Medicine Nashville, TN USA;3. Department of Pathology, Brigham and Women''s Hospital, Harvard Medical School Boston, MA USA;1. Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada R3T 2N2;2. Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A8;1. Department of Pathology, General Hospital of Daqing-oil-field, Daqing City, 163001, Heilongjiang Province, China;2. Department of Oncology, General Hospital of Daqing-oil-field, Daqing City, 163001, Heilongjiang Province, China;1. Department of Bioscience, College of Life Science, Nanchang University, Nanchang 330031, China;2. College of Materials and Chemical Engineering, Pingxiang University, Pingxiang 337055, China;1. CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;2. Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, The First Affiliated Hospital, China Medical University, Shenyang 110001, China;3. Department of Biochemistry and Molecular Biophysics, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, Columbia University Medical Center, Columbia University, New York NY, 10032, USA;1. Nordic Genetic Resource Center, Box 41, SE 230 53 Alnarp, Sweden;2. University of Latvia, Institute of Biology, Miera iela 3, Salaspils LV-2169, Latvia;3. Linköping University, IFM-Biology, SE 581 83 Linköping, Sweden;4. National Museum of Cultural History (Nordiska Museet), SE 643 98 Julita, Sweden;5. Swedish Board of Agriculture, Plant and Environment Department, Plant Regulations Division, SE 551 82 Jönköping, Sweden |
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| Abstract: | The Drosophila melanogaster white gene is a member of the ABC transporter superfamily of ATPase transmembrane proteins and is involved in the cellular uptake of guanine and tryptophan. We have cloned and sequenced human and mouse homologs of white which share 55–58% amino acid similarity with the Drosophila protein. Northern analysis reveals that the mammalian homolog is highly expressed in several tissues, including brain, spleen, lung and placenta. We have localized the gene to human chromosome 21q22.3 by means of fluorescence in situ hybridization and linkage analysis using a (CA)n polymorphism. The human homolog maps to the interval between D21S212 and D21S171, a region which includes loci for bipolar affective disorder and a recessive form of deafness. Since tryptophan is a precursor for the neurotransmitter serotonin and neurotoxic metabolites of the kynurenine pathway, we propose that the human homolog of white is a suitable candidate gene for these neurological disorders in humans. |
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