Type-4 pili of Kingella denitrificans |
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| Institution: | 1. Department of Molecular Biology and Microbiology, Tufts School of Medicine, 136 Hanison, Boston, MA 02111, USA;2. Department of Epidemiology, University of Michigan, 109 Observatory Street, Ann Arbor, MI 48105, USA;1. Mechanobiology Institute, Singapore, National University of Singapore, 117411, Republic of Singapore;2. Department of Biomedical Engineering, Singapore, National University of Singapore, 117411, Republic of Singapore;9. Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Methods Team, France;10. Université de Paris, 75006, Paris, France;11. Laboratoire d’Informatique de Grenoble (LIG), CNRS, 38401 Saint-Martin-d''Hères, France;12. Epistemonikos Foundation, Chile;13. Centre of Research in Epidemiology and StatisticS (CRESS UMR1153), Eren Team, 75013, Paris, France;14. Cochrane Germany, Cochrane Germany Foundation, 79110, Freiburg, Germany;15. Bordeaux Pharmacoepi - ADERA, France;p. Cochrane France, 75004, Paris, France;q. Laboratoire d''Informatique, de Modélisation et d''Optimisation des Systèmes (LIMOS), Université Clermont Auvergne, CNRS, 63178 Aubiere, France;r. Université Toulouse 3 – Paul Sabatier - Institut de Recherche en Informatique de Toulouse – IRIT UMR 5505, 31062 Toulouse, France;s. Institut des Systèmes Complexes de Paris IDF (ISC-PIF), CNRS, 75013, Paris, France;t. WHO Collaborating Centre for Guideline Implementation and Knowledge Translation & Chinese GRADE Centre, Lanzhou University, 730000, Gansu, China;u. Laboratoire de Recherche en Informatique (LRI), University Paris-Saclay, CNRS, 91405, Orsay, France;v. Université de Lyon, Université Lyon 1, CNRS, Laboratoire LIRIS, 69007, Lyon, France;w. Evidence Synthesis Ireland & Cochrane Ireland, National University of Ireland, Galway, Ireland;x. Centre for Evidence Based Medicine Odense (CEBMO), University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark;y. French National Research Institute for Agriculture, Food and Environment (INRAE), 75338, Paris, France;z. Service de Neurochirurgie, Hôpital d''Instruction des Armées Percy (HIA), 92140, Clamart, France;11. Adult Intensive Care Unit, Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico, University of Milan, 20122, Milano, Italy;22. Sanofi, 91380, Chilly-Mazarin, France;33. Cochrane South Africa, South African Medical Research Council, 7505 Tygerberg, South Africa;44. Department of Primary Education, University of Ioannina, 45110, Ioannina, Greece;55. Institute for Evidence in Medicine, Medical Center & Faculty of Medicine, University of Freiburg, 79110, Freiburg, Germany;66. Health Research Board-Trials Methodology Research Network (HRB-TMRN), NUI Galway, Ireland;77. Cochrane Chile, Evidence-Based Centre, Pontificia Universidad Católica de Chile, Santiago, Santiago Metropolitan Region, Chile;88. Nottingham Ningbo GRADE Centre, The Nottingham China Health Institute, The University of Nottingham Ningbo, 315100, Ningbo, China;99. Laboratoire d''Informatique pour la Mécanique et les Sciences de l''Ingénieur (LIMSI), CNRS, 91405, Orsay, France;1. Université de Paris, Centre of Research Epidemiology and Statistics (CRESS), Inserm, F-75004 Paris, France;2. Cochrane France, AP-HP, 75004 Paris, France;3. VisionsCarto, France;4. Ecole Centrale Lyon, LIRIS CNRS, 69134 Écully, France;5. INSA Lyon, LIRIS CNRS, 69621 Villeurbanne, France;6. Centre Max Weber, CNRS, 69007 Lyon, France;7. Laboratoire de Recherche en Informatique (LRI), Université Paris-Saclay, CNRS, 91405 Orsay, France;8. Centre d''Epidémiologie Clinique, Hôpital Hôtel Dieu, Assistance Publique des Hôpitaux de Paris (APHP), F-75004 Paris, France |
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| Abstract: | Kingella denitrificans possess type-4 pili, and the type strain, ATCC 33394, contains at least four complete copies of type-4 pilin-encoding genes. Previously reported hybridization patterns of K. denitrificans chromosomal DNA seen using a Neisseria gonorrhoeae pilin gene region probe, had been interpreted as representing possible partial, silent gene loci. This now appears to be due to cross-reaction to multiple copies of 18-bp inverted repeat structures. Data are presented on a variety of colony variants which have changed from a spreading-corroding (SC) phenotype to a nonspreading-noncorroding (N) phenotype. Interestingly, while the SC to N transition is most often associated with loss of piliation in other bacteria containing type-4 pili, many of the K. denitrificans N variants still produce pilin, and some still produce pili. |
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