Filamentous phage assembly: variation on a protein export theme |
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| Institution: | 1. School of Science and Technology, University of Sanya, Hainan, 572000, China;2. Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, 48858, United States;3. Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, United States;1. State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;2. Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;3. Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China;1. Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Università La Sapienza, 00185 Roma, Italy;1. Laboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao 266003, PR China;2. Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Aoshanwei Town, Qingdao, PR China |
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| Abstract: | Biogenesis of both filamentous phage and type-IV pili involves the assembly of many copies of a small, integral inner membrane protein (the phage major coat protein or pilin) into a helical, tubular array that passes through the outer membrane. The occurrence of related proteins required for assembly and export in both systems suggests that there may be similarities at the mechanistic level as well. This report summarizes the properties of filamentous phage and the proteins required for their assembly, with particular emphasis on features they may share with bacterial protein export and pilus biogenesis systems, and it presents evidence that supports the hypothesis that one of the phage proteins functions as an outer membrane export channel. |
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