A new hypothesis for Ca2+ flows in skeletal muscle and its implications for other cell types |
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Authors: | Mohammad Naimul Islam Raymond S Ochs |
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Institution: | (1) Department of Pharmaceutical Sciences, St. John's University, 8000 Utopia Parkway, 11439 Jamaica, NY |
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Abstract: | We offer a new hypothesis to explain calcium flows in skeletal muscle cells. Our model accounts for the uptake of Ca2+ from the extracellular fluid, and the release of Ca2+ from the sarcoplasmic reticulum (SR/ER) (the endoplasmic reticulum in muscle is named sarcoplasmic reticulum); this has engendered
difficulty in reviews encompassing both muscle and nonmuscle cells. Here we will typically refer to the organelle as ER, except
when specifically discussing muscle cells. The broad consideration of two major, still unexplained properties of skeletal
muscle function, namely excitation contraction coupling and capacitative calcium entry are accounted for in a unitary hypothesis.
This model allows a reinterpretation of existing data, and points to areas where new investigation may be fruitful. While
primarily aimed at explaining Ca2+ flows in skeletal muscle, we consider findings of other systems to explore the implications of this hypothesis for other
cell types. |
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Keywords: | Capacitative calcium entry store operated calcium entry excitation contraction coupling skeletal muscle heart cell dihydropyridine receptor L-channel ryanodine receptor |
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