| 三氯化铝对大鼠海马CA1区锥体细胞瞬间外向钾电流和延迟整流钾电流的影响 |
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| 引用本文： | Meng ZQ,Bai W. 三氯化铝对大鼠海马CA1区锥体细胞瞬间外向钾电流和延迟整流钾电流的影响[J]. 生理学报, 2003, 55(4): 401-404 |
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| 作者姓名： | Meng ZQ Bai W |
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| 作者单位： | 山西大学环境医学与毒理学研究所,山西大学环境科学与工程研究中心,太原,030006 |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (No. 30070647). |
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| 摘 要： | 采用全细胞膜片钳技术,研究了三氯化铝(AlCl3)对急性分离的大鼠海马CA1区神经元钾通道的影响。结果表明,AlCl3对钾电流有明显的抑制作用,具有一定的浓度依赖性,1000μmol／AlCl3可改变IA和IX激活曲线和失活曲线的Vb和k值,使钾电流激活曲线右移,使失活曲线左移。这些结果表明AlCl3对大鼠海马CA1区神经元K^ 通道有抑制作用,它可能是铝引起中枢神经系统损伤的机制之一。
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| 关 键 词： | 三氯化铝 海马 神经元 膜片钳技术 钾通道 |
| 修稿时间： | 2002-11-05 |
Effects of AlCl3 on transient outward K+ current and delayed rectifier K(+) current in acutely isolated rat hippocampal CA1 neurons |
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| Meng Zi-Qiang,Bai Wei. Effects of AlCl3 on transient outward K+ current and delayed rectifier K(+) current in acutely isolated rat hippocampal CA1 neurons[J]. Acta Physiologica Sinica, 2003, 55(4): 401-404 |
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| Authors: | Meng Zi-Qiang Bai Wei |
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| Affiliation: | MENG Zi-Qiang,BAI Wei Department of Environmental Science and Toxicology,Shanxi University,Taiyuan 030006 |
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| Abstract: | The effects of aluminum chloride (AlCl3) on the transient outward potassium and delayed rectifier K(+) current in hippocampal CA1 neurons of rats were studied by the whole-cell patch clamp technique. It was found that AlCl3 reduced the transient outward potassium current and delayed rectifier K(+) current in a dose-dependent manner. 1000 micromol/L AlCl3 resulted in change in voltage and slope of the half-activation and the half-inactivation of I(A) and I(K). These results imply that AlCl3 may damage potassium channel of the hippocampal CA1 neurons from rats and this may be related to the mechanism of the damage to the central nervous system by aluminum. |
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| Keywords: | aluminum chloride hippocampus neurons patch clamp techniques potassium channel |
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