7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase |
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| Authors: | Larsen Scott D Zhang Zhijun DiPaolo Brian A Manninen Peter R Rohrer Douglas C Hageman Michael J Hopkins Todd A Knechtel Mary L Oien Nancee L Rush Bob D Schwende Francis J Stefanski Kevin J Wieber Janet L Wilkinson Karen F Zamora Kathyrn M Wathen Michael W Brideau Roger J |
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| Institution: | Pfizer Global Research and Development, 2800 Plymouth Rd., Ann Arbor, MI 48105, USA. scott.d.larsen@pfizer.com |
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| Abstract: | We report a new class of non-nucleoside antivirals, the 7-oxo-4,7-dihydrothieno3,2-b]pyridine-6-carboxamides, some of which possess remarkable potency versus a broad spectrum of herpesvirus DNA polymerases and excellent selectivity compared to human DNA polymerases. A critical factor in the level of activity is hypothesized to be conformational restriction of the key 2-aryl-2-hydroxyethylamine sidechain by an adjacent methyl group. |
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