Synergistic anti-biofouling effect of Ag-exchanged zeolite and D-Tyrosine on PVC composite against the clinical isolate of Acinetobacter baumannii |
| |
| Authors: | Jelena Milenkovic Ivana Goic-Barisic Milos Tomic Jasna Djonlagic Nevenka Rajic |
| |
| Affiliation: | 1. Innovation Centre of the Faculty of Technology and Metallurgy, University of Belgrade, 11000 Belgrade, Serbia;2. Split University Hospital and School of Medicine, Department of Clinical Microbiology, University of Split, 21000 Split, Croatia;3. Faculty of Technology and Metallurgy, University of Belgrade, 11000 Belgrade, Serbia |
| |
| Abstract: | Due to their susceptibility to bacterial biofilm formation, commercial tubes for medical use are one of the main sources of hospital infections with Acinetobacter baumannii. The anti-biofouling activity of novel composites against the clinical isolate of the multi-drug resistant A. baumannii is reported here. The composites were prepared by addition of micronised silver-exchanged natural zeolite (Ag-NZ) into poly(vinyl chloride) (PVC), followed by coating of the composites with D-Tyrosine (D-Tyr). The Ag-NZ composites (containing 1–15 wt% of Ag-NZ) coated with D-Tyr (Ag-NZ-Tyr) showed a bactericidal effect (100% or a 6.9 log CFU reduction) towards immobilised bacterial cells. The uncoated Ag-NZ composites showed a reduction of up to 70% (4.4 log CFU) of immobilised bacteria in comparison with the original PVC. Rheological testing of the composites revealed that the addition of Ag-NZ slightly affected processability and formability of the PVC and increased the elasticity of the polymer matrix. |
| |
| Keywords: | antibacterial activity bacteria biofilm endotracheal tube public health |
|
|
