Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty |
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Authors: | A Roshan-Ghias A Terrier BM Jolles |
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Institution: | 1. Laboratory of Biomechanical Orthopedics, Ecole Polytechnique Fédérale de Lausanne, STI, IBI, Station 19, 1015 Lausanne, Switzerland;2. Service of Orthopaedic Surgery and Traumatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland |
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Abstract: | Bone defects in revision knee arthroplasty are often located in load-bearing regions. The goal of this study was to determine whether a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: (1) determining the mechanical stimulus using finite element method, (2) designing an animal study to measure bone formation spatially and temporally using micro-CT imaging in the scaffold subjected to the estimated mechanical stimulus, (3) identifying bone formation parameters for the loaded and non-loaded cases appearing in a recently developed mathematical model for bone formation in the scaffold and (4) estimating the stiffness and the bone formation in the bone-scaffold construct. With this procedure, we estimated that after 3 years mechanical stimulation increases the bone volume fraction and the stiffness of scaffold by 1.5- and 2.7-fold, respectively, compared to a non-loaded situation. |
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Keywords: | bone scaffold total knee implant revision mechanical loading in vivo finite element method translational medicine |
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