Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure |
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| Authors: | Morita Hideaki Khanal Sanjaya Rastogi Sharad Suzuki George Imai Makoto Todor Anastassia Sharov Victor G Goldstein Sidney O'Neill Timothy P Sabbah Hani N |
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| Institution: | Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, 2799 W. Grand Blvd., Detroit, MI 48202, USA. |
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| Abstract: | Matrix metalloproteinases (MMPs) contribute to the progression of left ventricular (LV) dysfunction and remodeling associated with heart failure (HF). The present study examined the long-term effects of a selective MMP inhibitor PG-530742 (PG) on the progression of LV dysfunction and remodeling in dogs with HF. Chronic HF LV ejection fraction (LVEF),
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