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A Trade-off Between Thermostability and Binding Affinity of Anti-(4-hydroxy-3-nitrophenyl)Acetyl Antibodies During the Course of Affinity Maturation |
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| Authors: | Nishiguchi Akihiro Murakami Akikazu Azuma Takachika Oda Masayuki |
| Institution: | 1.Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Shimogamo Hangi-cho, Sakyo-ku, Kyoto, 606-8522, Japan ;2.Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8504, Japan ;3.Antibody Technology Research Center, Inc, 2361-1Yamazaki, Noda, Chiba, 278-0022, Japan ; |
| Abstract: | The Protein Journal - Somatic hypermutation (SHM) is one of the driving forces that increases antibody (Ab) affinity. We studied the effects of SHM on thermostability and affinity using three... |
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