Chromanones with leishmanicidal activity from Calea uniflora |
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Authors: | do Nascimento Andréa Mendes Costa Fernanda Cristina Thiemann Otavio Henrique de Oliveira Dionéia Camilo Rodrigues |
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Affiliation: | Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeir?o Preto, Universidade de S?o Paulo, Via do Café s/n, 14040-903, Ribeir?o Preto, SP, Brazil. |
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Abstract: | The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6-(1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chromanones 1 and 2 showed significant growth inhibition of the parasite in the micrograms per milliliter range. |
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