A pathway map of glutamate metabolism |
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| Authors: | Soujanya D. Yelamanchi Savita Jayaram Joji Kurian Thomas Seetaramanjaneyulu Gundimeda Aafaque Ahmad Khan Anish Singhal T. S. Keshava Prasad Akhilesh Pandey Harsha Gowda |
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| Affiliation: | 1.Institute of Bioinformatics,Bangalore,India;2.School of Biotechnology,KIIT University,Bhubaneswar,India;3.Manipal University,Manipal,India;4.Amrita School of Biotechnology,Amrita Vishwa Vidyapeetham,Kollam,India;5.Kasturba Medical College,Manipal University,Mangalore,India;6.YU-IOB Center for Systems Biology and Molecular Medicine,Yenepoya University,Mangalore,India;7.McKusick-Nathans Institute of Genetic Medicine,Baltimore,USA;8.Department of Biological Chemistry,Johns Hopkins University School of Medicine,Baltimore,USA;9.Department of Pathology,Johns Hopkins University School of Medicine,Baltimore,USA;10.Department of Oncology,Johns Hopkins University School of Medicine,Baltimore,USA |
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| Abstract: | Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems. |
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