Cytological profiling: providing more haystacks for chemists' needles |
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Authors: | Janet Lorang Randall W King |
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Affiliation: | Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. |
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Abstract: | Conventional high-throughput 'chemical genetic' screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by affinity purification to identify targets of compounds with interesting effects, can lead to the identification of novel inhibitors. |
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