Expression of the calcium-activated potassium channel in upper and lower segment human myometrium during pregnancy and parturition |
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| Authors: | Lu Gao Binghai Cong Lanmei Zhang Xin Ni |
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| Affiliation: | (1) Department of Physiology, Second Military Medical University, 200433 Shanghai, PR China;(2) Department of Gynecology and Obstetric, Navy General Hospital, 100037 Beijing, PR China |
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| Abstract: | Background Large conductance calcium-activated potassium channel (BKCa) plays an important role in the control of uterine contractility during pregnancy. The change from uterine quiescence to enhanced contractile activity may be associated with the spatial and temporal expression of BKCa within myometrium. The objectives of this study were to examine the expression of BKCa alpha- and beta-subunit in upper segment (US) and lower segment (LS) regions of uterus, and to investigate for the possibly differential expression of these proteins in US and LS myometrium obtained from three functional states: (1) non-pregnant (NP); (2) term pregnant not in labour (TNL) and (3) term pregnant in labour (TL). |
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