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Metabolic engineering of a reduced-genome strain of Escherichia coli for L-threonine production |
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| Authors: | Jun Hyoung Lee Bong Hyun Sung Mi Sun Kim Frederick R Blattner Byoung Hoon Yoon Jung Hoe Kim Sun Chang Kim |
| Institution: | (1) Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea;(2) Biomass Team, Korea Institute of Energy Research, Daejeon, 305-343, Korea;(3) Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA;(4) Scarab Genomics, Madison, Wisconsin 53713, USA |
| Abstract: | BackgroundDeletion of large blocks of nonessential genes that are not needed for metabolic pathways of interest can reduce the production of unwanted by-products, increase genome stability, and streamline metabolism without physiological compromise. Researchers have recently constructed a reduced-genome Escherichia coli strain MDS42 that lacks 14.3% of its chromosome. |
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