Influence of conjugation reactions on the mutagenicity of aromatic amines |
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| Authors: | Jan Hongslo Peter J Wirth Mona Møller Erik Dybing Snorri S Thorgeirsson |
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| Institution: | 1. Central Institute of Industrial Research, P.O. Box 350, Blindern, Oslo 3, Norway;2. Department of Toxicology, National Institute of Public Health, Postuttak, Oslo 1, Norway;3. Laboratory of Carcinogen Metabolism, National Cancer Institute, Bethesda, MD 20205, U.S.A. |
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| Abstract: | 2-Acetylaminofluorene (AAF) and 2-aminofluorene (AF), as well as their N-hydroxylated metabolites, N-OH-AAF and N-OH-AF, were studied for mutagenic effects in Salmonella typhimurium with rat- and mouse-liver S9 and microsomal subfractions in the presence of cofactors for glucuronidation and glutathione (GSH) transfer. Addition of UDPGA did not affect the mutagenicity of AAF, AF or N-OH-AAF under any experimental condition. Addition of GSH, on the other hand, markedly inhibited AAF, AF and N-OH-AAF. This seemed to be due to the direct effect of GSH, and not through an enzyme-catalyzed conjugation. Further, GSH inhibited the direct mutagenicity of N-OH-AF. |
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| Keywords: | AAF 2-acetylaminofluorene AF 2-aminofluorene N-OH-AAF N-OH-AF GSH glutathione UDPGA uridine diphosphoglucuronic acid M MC 3-methylcholanthrene S9 Address for correspondence |
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