Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor |
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Authors: | S A Phillips N Perrotti S I Taylor |
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Institution: | Biochemistry and Molecular Pathophysiology Section, Diabetes Branch, NIDDK, National Institutes of Health, Building 10, Room 8N-250, Bethesda, MD 20892, USA |
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Abstract: | The receptors for insulin and epidermal growth factor possess tyrosine-specific protein kinase activity which may play a role in mediating the biological actions of these two peptides. We have identified a 120 kDa glycoprotein (pp120) in rat liver plasma membranes which can be phosphorylated by the insulin receptor in a cell-free system and in intact cultured hepatoma cells. In the present report, we have demonstrated in a cell-free system that solubilized epidermal growth factor receptors can phosphorylate tyrosine residues in pp120. |
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