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Recent developments in the monitoring,modeling and control of biological production systems
Authors:Carl-Fredrik?Mandenius  author-information"  >  author-information__contact u-icon-before"  >  mailto:cfm@ifm.liu.se"   title="  cfm@ifm.liu.se"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:(1) Division of Biotechnology, Linköping University, 581 83 Linköping, Sweden
Abstract:Current trends in the development of methods for monitoring, modeling and controlling biological production systems are reviewed from a bioengineering perspective. The ability to measure intracellular conditions in bioprocesses using genomics and other bioinformatics tools is addressed. Devices provided via micromachining techniques and new real-time optical technology are other novel methods that may facilitate biosystem engineering. Mathematical modeling of data obtained from bioinformatics or real-time monitoring methods are necessary in order to handle the dense flows of data that are generated. Furthermore, control methods must be able to cope with these data flows in efficient ways that can be implemented in plant-wide computer communication systems.Mini-review for the proceedings of the M3C conference
Keywords:Genomics and proteomics  Chemometrics  Multivariate process control  In situ optical sensors  Miniaturized devices  Control models
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