Enzymatic activity of thymidine kinases of a herpes simplex virus strains resistant to acyclovir H-phosphonates |
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| Authors: | A A Gus’kova M Yu Skoblov V L Andronova G A Galegov S N Kochetkov Yu S Skoblov |
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| Institution: | 1.Research Center for Medical Genetics,Russian Academy of Medical Sciences,Moscow,Russia;2.Ivanovskii Institute of Virology,Russian Academy of Medical Sciences,Moscow,Russia;3.Engelhardt Institute of Molecular Biology,Russian Academy of Sciences,Moscow,Russia;4.Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | Some cloned laboratory mutant strains of herpes simplex virus type I resistant to acyclovir H-phosphonate were studied. As was shown for all the clones, the mutations augmented the susceptibility to cidîfovir. Thymidine kinase of the mutant viruses partially retained the capacity to phosphorylate thymidine, but lost the capacity to phosphorylate BVDU. |
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